KT-881

C-Peptide ELISA Kit

Description

This human C-peptide ELISA kit is intended for use in the quantitative determination of human connecting peptide in serum and/or plasma.
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This ELISA kit is for in-vitro diagnostic use.

Background


C-peptide is a small 31-amino acid peptide usually produced in beta cells of the pancreas as a byproduct of the cleavage of proinsulin during the synthesis of insulin. Proinsulin consists of A and B chains and a connecting peptide in the middle, called C-peptide. It is generally found in equimolar amounts equal to insulin in circulation. Since the half-life of C-peptide is 3-4 times that of insulin, it serves as a useful measure of insulin production in the beta cells of the pancreas.

Testing for C-peptide levels can help find the cause of low blood sugar (hypoglycemia) and aid in distinguishing type 1 from type 2 diabetes. A person with diabetes may have a normal level of C-peptide which indicates the body is making plenty of insulin and simply not responding properly to it. This is the hallmark of type 2 diabetes (adult insulin-resistant diabetes). For patients with type 1 diabetes treated with insulin, measuring C-peptide levels is useful in evaluating beta cell function related to the synthesis and release of endogenous insulin into the circulation.
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Some studies have suggested that C-peptide may have chemotactic effects on inflammatory cells and might have a role in increased risk of atherosclerosis in persons with type-2 diabetes.

Specifications

Catalog no. KT-881
Target C-Peptide
Species Human
Method Sandwich ELISA
Tests Per Kit 96 tests
Detection Colorimetric
Sensitivity / LLOD 0.01 ng /mL
Dynamic Range 0 - 12 ng/mL
Total Incubation Time 1 hour, 20 minutes
Sample Type serum, EDTA-plasma
Sample Volume 50 µL
Storage Temperature 2-8 °C
For in-vitro diagnostic use.