KT-844

Fecal MPO Sample Collection Kit

Description

This Fecal MPO Sample Collection Kit is intended to be used with EDI Quantitative Fecal/Urine Myeloperoxidase ELISA Kit (KT-880) for the measurement of MPO in the gut . Each unit in this kit is specifically designed for easy collection of a small amount of stool sample into a pre-filled sample extraction buffer. 
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For in-vitro diagnostic use.

Background


Myeloperoxidase (MPO) is a specific polymorphonuclear enzyme that is most abundantly expressed in neutrophil granulocytes. It functions in the oxygen-dependent killing of microorganisms and is released from primary granules of neutrophils during acute inflammation. MPO is encoded by the MPO gene, which is about 11kb and composed of 11 introns and 12 exons, located in chromosome 17 (q12-24). The mature 150 kDa MPO protein is a dimer consisting of two 15kDA light chains and two heavy chains in variable degrees of glycosylation.
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MPO activity has been found to be linearly related to neutrophil cell count. Since neutrophils play a predominant role in inflammatory and immune reactions in inflammatory bowel disease (IBD) and MPO has been observed both in the intestinal mucosa and  gut lavage, the determination of MPO in stool sample provides one of the most sensitive and promising biomarkers in predicting disease severity.

Specifications

Catalog no. KT-844
Tests Per Kit 50 tubes
Storage Temperature 2-8 °C for up to 3 days, or -20°C for long term storage. Avoid more than 3 freeze-thaw cycles per specimen.
For in-vitro diagnostic use.