Deamidated Gliadin Peptide IgG CLIA Kit

Background

Deamidated gliadin peptide, DGP, is a modified form of gliadin, a protein found in foods containing gluten. In cases of celiac disease, the body produces immune system responses against these proteins, which harm the villi in the small intestine1. As the villi are damaged by these responses, their ability to aid in the absorption of nutrients decreases, which leads to symptoms including malnutrition and gastrointestinal issues2.

DGP-IgG is an antibody that can be produced as a reaction to the presence of gluten, and the measurement of the concentration of this antibody in the blood is used in the diagnosis of celiac disease. DGP-IgG tests offer high levels of specificity and sensitivity, and are especially useful in patients who have IgA deficiency3.

Selected Literature

1. Content - Health Encyclopedia - University of Rochester Medical Center. https://www.urmc.rochester.edu/encyclopedia/content?ContentTypeID=167&ContentID =dgp_celiac_disease

2. Harvard Health. Celiac disease. Harvard Health. Published July 18, 2023. https://www.health.harvard.edu/diseases-and-conditions/celiac disease#:~:text=When%20people%20with%20celiac%20disease%20eat%20foods%20 containing,fingerlike%20projections%20in%20the%20small%20intestine%20called%20 villi.

​​​​​​​3. Zingone F, Norman GL, Smecuol E, Maniero D, Carroccio A, Biagi F, Stefanolo JP, Niveloni S, Holmes G, Villanacci V, Santonicola A, Bai JC, Ciacci C. Utilizing both IgA tissue transglutaminase and IgG-deamidated gliadin peptide antibodies offers accurate celiac disease diagnosis without duodenal biopsy. Dig Liver Dis. 2025 Feb;57(2):609 615. doi: 10.1016/j.dld.2024.10.010. Epub 2024 Oct 29. PMID: 39472176.

For research use only. Not for use in diagnostics procedures.