Pepsinogen consists of a single polypeptide chain of 375 amino acids with an average
molecular weight of 42 kDa. Pepsinogen I is synthesized at gastric chief cells and
mucous neck cells, while pepsinogen II is produced not only by gastric chief cells,
mucous neck cells, but also by clear mucous cells of antrum, etc. Measuring pepsinogen I and pepsinogen II are of useful aid in evaluating severe atrophic gastritis, a possible prelude to stomach cancer. According to published liaterature (Samloff et al.), it was suggested that the measurement of
serum pepsinogens served as a “serological biopsy” for predicting the presence of
atrophic gastritis or superficial gastritis. The following is a summary from published literatures:
Atrophic Gastritis: It was found that a serum pepsinogen I with levels that fell to less than 20 ng/ml was highly specific for severe atrophic gastritis. It is also observed that serum
pepsinogen I levels fell with increasing severity of mucosal damage in atrophic gastritis. The diagnostic sensitivity and specificity of serum pepsinogen I levels for advanced atrophic corpus gastritis are about 92% and 90% respectively. On the other hand, the decrease in serum pepsinogen I levels in patients with pernicious anemia and atrophic
gastritis was found to be associated with normal or raised pepsinogen II levels.
Therefore, a pepsinogen I/pepsinogen II ratio is significantly lower than those with
superficial gastritis or normal remnant mucosa.
Stomach Cancer: Low serum pepsinogen I levels were found in patients with gastric
cancer, with a threefold higher incidence. Other studies have concluded that low serum pepsinogen I levels may identify persons at increased risk for intestinal types of stomach cancer.
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| Order Information |
Catalog No. KTR810, Pepsinogen
Kit: 96 tests
Method:"sandwich" immunoassay
Standards: 5 levels
Controls: 2 levels
Incubation: 1 h - 20 min, RT. static
Sample matrix: serum or plasma
Sample volume: 25 ul
Catalog No. KTR811, Pepsinogen II
Kit: 96 tests
Method: "sandwich" immunoassay
Standards: 5 levels
Controls: 2 levels
Incubation: 2 h - 20 min, RT, static
Sample matrix: serum or plasma
Sample volume: 50 ul
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Duodenal Ulcer: A low serum pepsinogen I level can exclude a diagnosis of duodenal ulcer. Although a high pepsinogen I level has less clinical useful for establishing the diagnosis of a duodenal ulcer, the combination of of hypergastrinemia and a highly elevated serum pepsinogen I strongly suggests the possibility of the Zollinger-Ellison syndrome.
For research use only. Not for use in diagnostic procedures.
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