Fetuin-A, also known as alpha-2-HS glycoprotein, is a 59 kDa glycoprotein that
consists of two amino-terminal cystatin domains and a smaller carboxyl-terminal
domain. Fetuin-A is synthesized by the liver and secreted into blood stream, where its
concentration in adult mammals ranges from 0.5 – 1.5 g/L. Fetuin-A occurs in high
serum concentration during fetal life and involves in protease inhibitory activities and
development-associated regulation of calcium metabolism and osteogenesis. It
accumulates in bones and teeth as a major fraction of noncollagenous bone proteins.
Biologically, studies have demonstrated that Fetuin-A is the major calcification inhibitor
found in serum, where it interferes with calcium salt precipitation. A Fetuin-A gene
knockout mouse develops massive cardiovascular and soft tissue calcification. |
| Order Information |
Catalog No.: KT-800
Kit: 96 tests
Method: “sandwich” immunoassay
Standards: 5 levels
Controls: 2 levels
Incubation: 2 h – 30 min – 20 min, RT
Sample matrix: serum or plasma
Sample volume: 10 µl
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