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Chromogranin A is a 49 kDa acidic protein that consists of 439 amino acids encoded
on chromosome 14. Chromogranin A has been identified in a number of normal and
neopastic endocrine tissues. It was demonstrated that an elevated circulating
chromogranin A level would be a marker of tumors of neuroendocrine origin.
However, the traditional application of chromogranin A is related to pheochromocytoma. The following is a short
summary of the uses of chromogranin A, according to published literature: |
| Order Information |
Catalog No.: KT-820
Kit: 96 tests
Method: "sandwich" immunoassay
Standards: 5 levels
Controls: 2 levels
Incubation: 1 hr - 1 hr - 20 min, RT
Sample matrix: serum or plasma
Sample volume: 15 ul
No "hook" tested at 1,000,000 ng/ml
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1. A very sensitive (83%) and highly specific (96%) marker in the evaluation of
actual or suspected pheochromocytoma. Drugs commonly employed in the diagnosis
or treatment of pheochromocytoma have little effect on the plasma chromogranin A
level, which is a great advantage toward measuring chromogranin A over catacholamines.
2. To ascertain the source of a tumor. A high chromogranin A level indicates that the tumor arises from neuroendocrine
tissues.
3. Detecting endocrine tumors that do not produce their specific hormones, for example, calcitonin negative but chromogranin A
positive C-cell carcinoma; zero-cell carcinoma; beta-cell carcinoma; parathyroid carcinoma.
4. Detecting gastro-intestinal tumor.
5. Evaulating prostate cancer. A higher level of Chromogranin A indicates a higher neuron/endocrine activity of the prostate cancer and
an in-effective treatment.
6. To ascertain prognostic value in patients with myocardial infarction.
This kit is CE marked and for IVD use in Europe.
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Other related products:
(1) Six different polyclonal antibodies available which bind to diffferent epitopes of chromogranin A
(2) Monoclonal anti-chromogranin A antibody for immunohistochemistry staining
(3) HRP-conjugated anti-chromogranin A antibody
(4) HRP conjugated streptavidin
(5) Streptavidin coated plastic bead (ø 5/16")
(6 )Streptavidin coated microtiter plate
Literature links:
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