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Human Fetuin-A ELISA Kit

adobe Published papers featuring this assay

Fetuin-A, also known as alpha-2-HS glycoprotein, is a 59 kDa glycoprotein that
consists of two amino-terminal cystatin domains and a smaller carboxyl-terminal
domain. Fetuin-A is synthesized by the liver and secreted into blood stream, where its
concentration in adult mammals ranges from 0.5 – 1.5 g/L. Fetuin-A occurs in high
serum concentration during fetal life and involves in protease inhibitory activities and
development-associated regulation of calcium metabolism and osteogenesis. It
accumulates in bones and teeth as a major fraction of noncollagenous bone proteins.
Biologically, studies have demonstrated that Fetuin-A is the major calcification inhibitor
found in serum, where it interferes with calcium salt precipitation. A Fetuin-A gene
knockout mouse develops massive cardiovascular and soft tissue calcification.

This kit is CE marked and for IVD use in Europe.

Order Information
Catalog No.: KT-800
Kit: 96 tests
Method: “sandwich” immunoassay
Standards: 5 levels
Controls: 2 levels
Incubation: 2 h – 30 min – 20 min, RT
Sample matrix: serum or plasma
Sample volume: 10 µl
Recent clinical studies have demonstrated that circulating Fetuin-A level drops in chronic kidney failure patients and ESRD patients on hemodialysis in comparison to normal healthy controls. Clinical studies have demonstrated that there is an inverse correlation of serum Fetuin-A level and cardiovascular calcification score in these patients. The low Fetuin-A level shows a strong associates with a higher cardiovascular mortality in patients on dialysis.


Low serum fetuin-A levels predicts atherosclerosis and mortality in end-stage renal disease patients (n=258) and are associated with malnutrition, inflammation, atherosclerosis and genetic variations in the gene (AHSG) encoding fetuin. P. Stenvinkel, et al. Kidney Int. 2005, 2380-2392

Other related products:
(1)Polyclonal anti-human Fetuin-A antibody for immunohistochemistry staining
(2)HRP-conjugated polyclonal anti-Fetuin-A antibody
(3)Streptavidin coated plastic bead (ø 5/16”)
(4)Streptavidin coated microtiter plate

Literature Links:
(2)Medscape & eMedicine fetuin-A from http://www.medscape.com