Human Chromogranin A ELISA Kit

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Comparison of available chromogranin A assays

Comparison of available chromogranin A assays

Description

This ELISA (enzyme-linked immunosorbent assay) kit is intended for the quantitative measurement of human chromogranin A levels in EDTA-plasma and serum samples. This assay exclusively measures human chromogranin A without the high dose "hook" effect up to 1,000,000 ng/ml. This test may be used as an aid for detecting  pheochromocytoma and neuroendocrine tumors in patients.

This kit has a wider measurement range than the standard CgA ELISA kit (KTR-820)

This chromogranin A ELISA kit is for research use only.

Background

Chromogranin A is a 49 kDa acidic protein that consists of 439 amino acids encoded on chromosome 14. Chromogranin A has been identified in a number of normal and neoplastic endocrine tissues. It is demonstrated that an elevated level of circulating chromogranin A is a marker for tumors of neuroendocrine origin. However, the most significant clinical use of chromogranin A is related to the diagnostic procedure in patients with pheochromocytoma. The following is a short summary of the potential usages of chromogranin A. 

1.       A very sensitive (83%) and highly specific (96%) marker in the evaluation of actual or suspected pheochromocytoma. Drugs commonly employed in the diagnosis or treatment of pheochromocytoma have little effect on plasma chromogranin A levels, which is a great advantage over the measurement of catecholamines. 

2.       To ascertain the source of a tumor. A high chromogranin A level indicates that the tumor arises from neuroendocrine tissues.

3.       Endocrine tumors that do that produce their specific hormones, for example, calcitonin negative but chromogranin A positive C-cell carcinoma; zero-cell carcinoma; beta-cell carcinoma; parathyroid carcinoma.

Related Kits

KTR-820 Human Chromogranin A ELISA Kit

 

Specifications

 

Catalog no.

Target:

Species

Method

Tests Per Kit

Detection

Sensitivity / LLOD

Dynamic Range

Total Incubation Time

Sample Type

Sample Volume

Storage Temperature

 

KTR-855

Chromogranin A (CHGA, CgA)

Human

Sandwich ELISA

96 tests

Colorimetric

1.4 ng /mL

0 - 2500 ng/mL

2 hour, 20 minutes

Serum, EDTA-plasma

15 µL

2-8 °C

For research use only.