Hepatitis E Virus IgG ELISA Kit
This is an Enzyme ImmunoAssay (ELISA) for the determination of IgG antibody to Hepatitis E Virus in human plasma and serum.
The kit is for research use only.
Hepatitis E (HEV) viral particles are 27 to 34 nanometers in diameter, are non-enveloped and contain a single-strand of positive-sense RNA that is approximately 7300 bases in length. The RNA molecule contains three discontinuous and partially overlapping open reading frames (ORFs) along with 5' and 3' cis-acting elements, which have important roles in HEV replication and transcription. ORF1 encode a methyltransferase, protease, helicase and replicase; ORF2 encode the capsid protein and ORF3 encodes a protein of undefined function.
The incubation period following exposure to HEV ranges from 3 to 8 weeks, with a mean of 40 days. The period of communicability is unknown. There are no chronic infections reported. Hepatitis E virus causes acute sporadic and epidemic viral hepatitis. Symptomatic HEV infection is most common in young adults aged 15-40 years. Although HEV infection is frequent in children, it is mostly asymptomatic or causes a very mild illness without jaundice (anicteric) that goes undiagnosed. Typical signs and symptoms of hepatitis include jaundice (yellow discoloration of the skin and sclera of the eyes, dark urine and pale stools), anorexia (loss of appetite), an enlarged, tender liver (hepatomegaly), abdominal pain and tenderness, nausea and vomiting, and fever, although the disease may range in severity from subclinical to fulminant.
Both IgM and IgG subtypes of antibodies can be detected in patients with hepatitis E after 3 – 4 weeks of infection. The IgM subtype of anti-HEV antibody would disappear after week 15, whereas, the IgG subtype of anti-HEV antibody would remain high titer.
This kit is part of the Epitope Diagnostics ToRCH panel.
Tests Per Kit
Total Incubation Time
Hepatitis E Virus
For research use only. Not for use in diagnostic procedures.